Protecting organs, saving lives

Martin J. Mangino, Ph.D., has a clinical interest in saving both organs and lives. Mangino, a professor at Virginia Commonwealth University's School of Medicine, is also a laboratory director and research director of the VCU Trauma Center. Mangino’s team has two main objectives.

The first objective is preserving and protecting ischemic organs that would normally be damaged and, therefore, not suitable for transplants. Their novel approaches have a range of benefits from growing the organ donor pool and bringing organs back to life, to countering organ rejection.

“Resuscitation from lethal hemorrhagic shock with these new solutions increases the golden hour tenfold compared to what we currently use. Innovation Gateway is making it possible to successfully translate these findings into lifesaving clinical products.”

Martin J. Mangino, Ph.D.
Department of Surgery

The second is extending the "golden hour," that crucial window of time a patient has to get to the hospital for survival after hemorrhagic shock. They are experimenting with solutions that increase capillary flow in the event of blood loss, ultimately reversing the shock state shortly after resuscitation. For trauma patients, this means safer and longer transport times and a much greater survival rate.

By all indications, Mangino’s mission to create golden hours of opportunity is a success. His team’s research is currently being funded by the National Institutes of Health and the Department of Defense, specifically in exploring life-saving solutions for battlefield care where every second counts.