Biomedical, Engineering and physical science
Anticoagulant Intellectual Property Portfolio Sulfated Heparin Mimetics
The current treatment and prevention of thromboembolic diseases, Heparin, has numerous disadvantages. Heparins usually consist of a heterogeneous mixture, and thus contain many additional ingredients which result in a variety of side effects. Concern has also arisen with the purity and safety of the supply of heparin. Additionally, heparins are highly sulfated molecules, and thus highly hydrophilic and result in poor bioavailability. Some of the side effects observed with heparin usage are thrombocytopenia, osteoporosis, as well as concern if the dosage is incorrect and the patient is overdosed. There is a clinical need for a new anticoagulant with heparin-like activity without the many potentially lethal side effects currently observed with its use.
Nonpathogenic Bacteria Derived – Developed process for making low molecular weight heparosan and cleaving enzymes.
Chemically Derived – Chemically synthesized sulfated low molecular weight lignins that shows potent anticoagulant activity both in vitro and ex vivo were synthesized.
Factor XIa inhibitors – These small molecules may be the most promising group of direct inhibitors. The developed molecules include sulfated gallic acids, sulfated inositol analogs, and sulfated quinazolinones. These compounds act via an entirely new allosteric mechanism, providing higher efficacy and safety.
In-vitro and ex vivo studies demonstrate efficacy
More publications can be found on Dr. Desai’s webpage